Inhibition of IL-12 signaling Stat4/IFN-gamma pathway by rapamycin is associated with impaired dendritic [correction of dendritc] cell function

Transplant Proc. 2002 Aug;34(5):1394-5. doi: 10.1016/s0041-1345(02)02900-7.

Authors

P-H Chiang¹, L Wang, Y Liang, X Liang, S Qian, J J Fung, C A Bonham, L Lu

Affiliation

¹ Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15261, USA.

PMID: 12176411
DOI: 10.1016/s0041-1345(02)02900-7

No abstract available

MeSH terms

Animals
Bone Marrow Cells / drug effects
Bone Marrow Cells / immunology
DNA-Binding Proteins / antagonists & inhibitors*
Dendritic Cells / drug effects
Dendritic Cells / immunology*
Flow Cytometry / methods
Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology
Heart Transplantation / immunology
Interferon-gamma / antagonists & inhibitors*
Interleukin-12 / antagonists & inhibitors*
Mice
Mice, Inbred C3H
STAT4 Transcription Factor
Signal Transduction / drug effects
Signal Transduction / immunology*
Sirolimus / pharmacology*
Trans-Activators / antagonists & inhibitors*

Substances

DNA-Binding Proteins
STAT4 Transcription Factor
Stat4 protein, mouse
Trans-Activators
Interleukin-12
Interferon-gamma
Granulocyte-Macrophage Colony-Stimulating Factor
Sirolimus