Abstract
Direct visualization and quantification of antigen-specific T cells using major histocompatibility complex (MHC)/peptide tetramer technology offers a powerful means to study specific T cell populations of interest. In combination with functional assays, this technology has already provided many new insights into several long-standing immunological concepts in basic science as well as clinical settings.
MeSH terms
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Apoptosis
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Autoimmunity
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Graft Rejection
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Histocompatibility Antigens Class I / chemistry*
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Histocompatibility Antigens Class I / metabolism*
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Humans
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Immunotherapy
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In Vitro Techniques
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Lymphocyte Activation
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Models, Immunological
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Neoplasms / immunology
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Neoplasms / therapy
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Protein Structure, Quaternary
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Signal Transduction
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology*
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T-Lymphocytes, Cytotoxic / cytology
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T-Lymphocytes, Cytotoxic / immunology
Substances
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Histocompatibility Antigens Class I