MHC/peptide tetramer-based studies of T cell function

J Immunol Methods. 2002 Oct 1;268(1):21-8. doi: 10.1016/s0022-1759(02)00196-5.

Abstract

Direct visualization and quantification of antigen-specific T cells using major histocompatibility complex (MHC)/peptide tetramer technology offers a powerful means to study specific T cell populations of interest. In combination with functional assays, this technology has already provided many new insights into several long-standing immunological concepts in basic science as well as clinical settings.

Publication types

  • Review

MeSH terms

  • Apoptosis
  • Autoimmunity
  • Graft Rejection
  • Histocompatibility Antigens Class I / chemistry*
  • Histocompatibility Antigens Class I / metabolism*
  • Humans
  • Immunotherapy
  • In Vitro Techniques
  • Lymphocyte Activation
  • Models, Immunological
  • Neoplasms / immunology
  • Neoplasms / therapy
  • Protein Structure, Quaternary
  • Signal Transduction
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes, Cytotoxic / cytology
  • T-Lymphocytes, Cytotoxic / immunology

Substances

  • Histocompatibility Antigens Class I