Background: Epiluminescence light microscopy (ELM) can be improved with enhanced optical resolution.
Objective: High-resolution ELM was performed by placing a standard light microscope on the skin surface for visualization of further details.
Methods: 25 melanocytic nevi and 14 melanomas with a globular pattern were investigated and examined histologically.
Results: A new spotty substructure was detected, namely individual pigmented spots of 5-10 micro m in diameter located within peripheral brown globules. Clinicopathologic correlation showed these spots to correspond with individual pigmented melanocytes (IPMs) within nests of melanocytes. IPMs were seen in 9/25 melanocytic nevi and in none of 14 melanomas.
Conclusion: Their origin may be a physiologic, UV-dependent pigment induction suggesting that they may represent a benign ELM pattern.
Copyright 2002 S. Karger AG, Basel