Specific recruitment of human cohesin to laser-induced DNA damage

J Biol Chem. 2002 Nov 22;277(47):45149-53. doi: 10.1074/jbc.M209123200. Epub 2002 Sep 12.

Abstract

Cohesin is a conserved multiprotein complex that plays an essential role in sister chromatid cohesion. During interphase, cohesin is required for the establishment of cohesion following DNA replication. Because cohesin mutants resulted in increased sensitivity to DNA damage, a role for cohesin in DNA repair was also suggested. However, it was unclear whether this was due to general perturbation of cohesion or whether cohesin has a specialized role at the damage site. We therefore used a laser microbeam to create DNA damage at discrete sites in the cell nucleus and observed specific in vivo assembly of proteins at these sites by immunofluorescent detection. We observed that human cohesin is recruited to the damage site immediately after damage induction. Analysis of mutant cells revealed that cohesin recruitment to the damage site is dependent on the DNA double-strand break repair factor Mre11/Rad50 but not ATM or Nbs1. Consistently, Mre11/Rad50 and cohesin interact with each other in an interphase-specific manner. This interaction peaks in S/G(2) phase, during which cohesin is recruited to the DNA damage. Our results demonstrate the S/G(2)-specific and Mre11/Rad50-dependent recruitment of human cohesin to DNA damage, suggesting a specialized subfunction for cohesin in cell cycle-specific DNA double strand break repair.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acid Anhydride Hydrolases
  • Cell Cycle / physiology
  • Cell Cycle Proteins
  • Cell Nucleus / metabolism
  • Cell Nucleus / radiation effects
  • Chromosomal Proteins, Non-Histone
  • Cohesins
  • DNA / genetics
  • DNA / metabolism
  • DNA / radiation effects*
  • DNA Damage*
  • DNA Repair
  • DNA Repair Enzymes*
  • DNA-Binding Proteins / metabolism
  • Fibroblasts / metabolism
  • Fibroblasts / radiation effects
  • Fungal Proteins
  • HeLa Cells
  • Humans
  • Lasers* / adverse effects
  • MRE11 Homologue Protein
  • Macromolecular Substances
  • Models, Genetic
  • Multiprotein Complexes
  • Nuclear Proteins / metabolism*

Substances

  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • Fungal Proteins
  • MRE11 protein, human
  • Macromolecular Substances
  • Multiprotein Complexes
  • Nuclear Proteins
  • DNA
  • MRE11 Homologue Protein
  • Acid Anhydride Hydrolases
  • RAD50 protein, human
  • DNA Repair Enzymes