Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection

J Virol. 2002 Oct;76(20):10507-11. doi: 10.1128/jvi.76.20.10507-10511.2002.

Abstract

Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology
  • Cell Division
  • Epitopes, T-Lymphocyte / immunology*
  • Gene Products, gag / immunology*
  • Histocompatibility Antigens Class I / immunology*
  • Humans
  • Immunodominant Epitopes / immunology*
  • Macaca mulatta
  • Simian Immunodeficiency Virus / immunology*
  • T-Lymphocytes, Cytotoxic / immunology*
  • Vaccination

Substances

  • Epitopes, T-Lymphocyte
  • Gene Products, gag
  • Histocompatibility Antigens Class I
  • Immunodominant Epitopes
  • Mamu-A 01 antigen