CXC-chemokines KC and macrophage inflammatory protein-2 (MIP-2) synergistically induce leukocyte recruitment to the central nervous system in rats

Petra J G Zwijnenburg; Machteld M J Polfliet; Sandrine Florquin; Timo K van den Berg; Christine D Dijkstra; Sander J H van Deventer; John J Roord; Tom van der Poll; A Marceline van Furth

doi:10.1016/s0165-2478(02)00200-6

CXC-chemokines KC and macrophage inflammatory protein-2 (MIP-2) synergistically induce leukocyte recruitment to the central nervous system in rats

Immunol Lett. 2003 Jan 2;85(1):1-4. doi: 10.1016/s0165-2478(02)00200-6.

Authors

Petra J G Zwijnenburg¹, Machteld M J Polfliet, Sandrine Florquin, Timo K van den Berg, Christine D Dijkstra, Sander J H van Deventer, John J Roord, Tom van der Poll, A Marceline van Furth

Affiliation

¹ Department of Pediatrics, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. p.j.zwijnenburg@amc.uva.nl

PMID: 12505189
DOI: 10.1016/s0165-2478(02)00200-6

Abstract

Intracisternal injection of the CXC-chemokines KC or macrophage inflammatory protein (MIP)-2 induced a pleocytosis in the cerebrospinal fluid (CSF) of rats in a dose dependent way. MIP-2 was much more potent than KC. The concurrent injection of both chemokines revealed a profound synergistic effect on leukocyte recruitment into CSF.

MeSH terms

Animals
Brain / cytology
Central Nervous System / physiology*
Chemokine CXCL2
Chemokines, CXC / cerebrospinal fluid*
Chemokines, CXC / pharmacology*
Chemotactic Factors / pharmacology*
Dose-Response Relationship, Immunologic
Drug Synergism
Male
Monokines / pharmacology*
Neutrophils / drug effects*
Neutrophils / physiology
Rats
Rats, Wistar

Substances

Chemokine CXCL2
Chemokines, CXC
Chemotactic Factors
Monokines