Abstract
Transient CD154 blockade at the onset of Theiler's murine encephalomyelitis virus-induced demyelinating disease ameliorated disease progression for 80 days, reduced immune cell infiltration, and transiently increased viral loads in the central nervous system. Peripheral antiviral and autoimmune T-cell responses were normal, and disease severity returned to control levels by day 120.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Antibodies / therapeutic use*
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CD40 Ligand / physiology*
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Cardiovirus Infections / immunology
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Cardiovirus Infections / pathology
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Cardiovirus Infections / therapy*
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Demyelinating Diseases / immunology
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Demyelinating Diseases / pathology
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Demyelinating Diseases / therapy*
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Hypersensitivity, Delayed / etiology
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Mice
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Molecular Sequence Data
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Spinal Cord / pathology
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Spinal Cord / virology
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Th1 Cells / immunology
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Theilovirus*
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Viral Load