Cyclosporin A and methotrexate are equally effective in reducing T cell numbers in psoriatic skin lesions but have no consistent effect on IFN-gamma and IL-4 expression in psoriatic skin in situ

Arch Dermatol Res. 2003 Mar;294(12):559-62. doi: 10.1007/s00403-002-0353-8. Epub 2002 Dec 14.
No abstract available

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Cyclosporine / therapeutic use*
  • Female
  • Humans
  • Immunohistochemistry
  • Immunosuppressive Agents / therapeutic use
  • Interferon-gamma / metabolism*
  • Interleukin-4 / metabolism*
  • Lymphocyte Count
  • Male
  • Methotrexate / therapeutic use*
  • Middle Aged
  • Prospective Studies
  • Psoriasis / drug therapy*
  • Psoriasis / immunology
  • Psoriasis / pathology
  • T-Lymphocytes / drug effects*
  • T-Lymphocytes / pathology

Substances

  • Immunosuppressive Agents
  • Interleukin-4
  • Interferon-gamma
  • Cyclosporine
  • Methotrexate