Molecular cytogenetic analysis of a pleuropulmonary blastoma

Cancer Genet Cytogenet. 2003 Apr 1;142(1):65-9. doi: 10.1016/s0165-4608(02)00731-8.

Abstract

We report a case of pleuropulmonary blastoma with complex cytogenetic abnormalities, including trisomy 2, trisomy 8, dup(7), der(10) t(8; 10)(q13; q22), add(17), and double minutes (dmin). Fluorescence in situ hybridization FISH analysis demonstrated TP53 deletion and amplification of MYCN; the latter has not been reported in PPB.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Chromosome Aberrations*
  • Chromosomes, Human*
  • Cytogenetic Analysis
  • Female
  • Gene Deletion
  • Humans
  • In Situ Hybridization, Fluorescence
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / pathology
  • N-Myc Proto-Oncogene Protein
  • Nuclear Proteins / genetics*
  • Oncogene Proteins / genetics*
  • Pulmonary Blastoma / drug therapy
  • Pulmonary Blastoma / genetics*
  • Pulmonary Blastoma / pathology
  • Trisomy
  • Tumor Suppressor Protein p53 / genetics

Substances

  • MYCN protein, human
  • N-Myc Proto-Oncogene Protein
  • Nuclear Proteins
  • Oncogene Proteins
  • Tumor Suppressor Protein p53