Abstract
In the course of our screening for bacterial phospho-N-acetylmuramyl-pentapeptide-translocase (translocase I: EC 2.7.8.13) inhibitors, we found inhibitory activity in the cultured broth of the strain identified as Streptomyces griseus SANK 60196. The strain produced capuramycin and four novel capuramycin derivatives designated as A-500359 A, C, D and G. Purification and structural analysis were performed, and the structures of A-500359 A, C, D and G were elucidated as 6'''-methylcapuramycin, 3'-demethyl-6'''-methylcapuramycin, 2''-deoxy-6'''-methylcapuramycin and 3'-demethylcapuramycin, respectively.
MeSH terms
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Aminoglycosides*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / classification*
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Azepines / chemistry
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Azepines / classification*
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Azepines / isolation & purification
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Azepines / pharmacology
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Bacteria / enzymology*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / classification*
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology
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Fermentation
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Stereoisomerism
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Streptomyces / chemistry
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Transferases (Other Substituted Phosphate Groups) / antagonists & inhibitors*
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Uridine / analogs & derivatives*
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Uridine / chemistry
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Uridine / classification
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Uridine / isolation & purification
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Uridine / pharmacology
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Azepines
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Enzyme Inhibitors
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capuramycin
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Transferases (Other Substituted Phosphate Groups)
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phospho-N-acetylmuramoyl pentapeptide transferase
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Uridine