Randomized controlled trials in psychiatry. Part 1: methodology and critical evaluation

Aust N Z J Psychiatry. 2003 Jun;37(3):257-64. doi: 10.1046/j.1440-1614.2003.01175.x.

Abstract

Objective: To introduce clinicians to the methodology and critical appraisal of randomized controlled trials (RCTs) in psychiatry.

Method: The methodology of RCTs in psychiatry is discussed. Using a systematic approach to critical appraisal, a published RCT of treatments for severe depression is examined and evaluated.

Results and conclusions: The RCT appraised illustrates certain problematic areas in the methodology of trials in psychiatry. A detailed knowledge of methodology and critique of RCTs is essential in determining whether reported results will influence clinicians' practice.

Publication types

  • Evaluation Study

MeSH terms

  • Cyclohexanols / therapeutic use
  • Depressive Disorder / drug therapy
  • Depressive Disorder / psychology*
  • Double-Blind Method
  • Humans
  • Patient Selection
  • Psychiatry / methods*
  • Randomized Controlled Trials as Topic / standards*
  • Selective Serotonin Reuptake Inhibitors / therapeutic use
  • Venlafaxine Hydrochloride

Substances

  • Cyclohexanols
  • Serotonin Uptake Inhibitors
  • Venlafaxine Hydrochloride