Effect of atorvastatin on myocardial contractile reserve assessed by tissue Doppler imaging in moderately hypercholesterolemic patients without heart disease

Am J Cardiol. 2003 Sep 1;92(5):613-6. doi: 10.1016/s0002-9149(03)00737-9.

Abstract

An improvement in myocardial longitudinal systolic velocities, assessed by pulsed-wave tissue Doppler imaging during low-dose dobutamine infusion, was observed at 6-month follow-up after 6 months of treatment with atorvastatin. Our findings indicate a favorable effect of atorvastatin on contractile reserve, possibly through an enhancement of flow-dependent coronary dilatation during stress.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Atorvastatin
  • Blood Flow Velocity / drug effects
  • Blood Pressure / drug effects
  • Cardiotonic Agents
  • Cholesterol, HDL / blood
  • Cholesterol, HDL / drug effects
  • Cholesterol, LDL / blood
  • Cholesterol, LDL / drug effects
  • Diastole / drug effects
  • Diet, Fat-Restricted
  • Dobutamine
  • Echocardiography, Doppler / instrumentation
  • Echocardiography, Doppler / methods*
  • Female
  • Follow-Up Studies
  • Heart Rate / drug effects
  • Heptanoic Acids / therapeutic use*
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Hypercholesterolemia / blood
  • Hypercholesterolemia / diagnostic imaging*
  • Hypercholesterolemia / drug therapy*
  • Hypercholesterolemia / physiopathology
  • Male
  • Middle Aged
  • Myocardial Contraction / drug effects*
  • Pyrroles / therapeutic use*
  • Stroke Volume / drug effects
  • Systole / drug effects
  • Treatment Outcome
  • Triglycerides / blood

Substances

  • Cardiotonic Agents
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Heptanoic Acids
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Pyrroles
  • Triglycerides
  • Dobutamine
  • Atorvastatin