Abstract
A polymorphic restriction site has been found in intron 11 of the gene for glucose-6-phosphate dehydrogenase (G6PD). This site is produced by a T----C substitution 13 bp upstream of exon 12, producing an NlaIII restriction site. In various populations there was a strong association between a T at nt 1311 of the G6PD cDNA and the presence of the NlaIII restriction site. Among African Americans, however, the presence of a C at nt 1311 was sometimes associated with the presence of a polymorphic NlaIII site.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Base Sequence
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Black People / genetics
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DNA Mutational Analysis
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Deoxyribonucleases, Type II Site-Specific / genetics*
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Ethnicity
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Genes / genetics*
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Glucosephosphate Dehydrogenase / genetics*
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Humans
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Molecular Sequence Data
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Mutation
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Polymorphism, Restriction Fragment Length*
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Restriction Mapping
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United States
Substances
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Glucosephosphate Dehydrogenase
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endodeoxyribonuclease NlaIII
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Deoxyribonucleases, Type II Site-Specific