Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes

Genomics. 1992 Aug;13(4):1356-8. doi: 10.1016/0888-7543(92)90069-5.

Abstract

The genes for three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), have been regionally localized on chromosomes 13, 2, and 7, respectively, by interspecific backcross analysis. These results refine previous localizations by in situ hybridization as well as confirm and extend known regions of homology between mouse and human chromosomes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromosome Mapping*
  • Crosses, Genetic
  • Furin
  • Mice
  • Mice, Inbred C57BL
  • Polymorphism, Restriction Fragment Length
  • Subtilisins / genetics*

Substances

  • Subtilisins
  • Furin