New classes of selective D-1 dopamine receptor antagonist provide further evidence for two directions of D-1:D-2 interaction

Neurochem Int. 1992 Mar:20 Suppl:135S-139S. doi: 10.1016/0197-0186(92)90226-h.

Abstract

Initial notions of cooperative/synergistic interactions between D-1 and D-2 dopamine receptors have been followed by recent evidence suggesting more complex forms of D-1:D-2 interaction. Each of the new, putative selective D-1 antagonists SCH 39166, NO 756 and A-69024 antagonised typical behavioural responses to the selective D-2 agonist RU 24213 and concurrently released atypical behaviour. These data extend new notions of both cooperative/synergistic and oppositional D-1:D-2 interactions in the regulation of typical and atypical behaviours, which may involve further subtypes of D-1 and of D-2 receptor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Dopamine Agonists / pharmacology
  • Dopamine Antagonists / classification*
  • Humans
  • Phenethylamines / pharmacology
  • Receptors, Dopamine D1 / antagonists & inhibitors*
  • Receptors, Dopamine D1 / physiology*
  • Receptors, Dopamine D2 / physiology*

Substances

  • Dopamine Agonists
  • Dopamine Antagonists
  • Phenethylamines
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • N-n-propyl-N-phenylethyl-4(3-hydroxyphenyl)ethylamine hydrochloride