Glucagon-like peptide-1(7-37)/(7-36)amide is a new incretin

Mol Cell Endocrinol. 1992 May;85(1-2):C39-44. doi: 10.1016/0303-7207(92)90118-p.

Abstract

Glucagon-like peptide-1 (GLP-1) is the main product of the intestinal processing of proglucagon. It is released from the intestinal K-cells into the circulation in response to the oral ingestion of food. At the pancreatic beta cell GLP-1 is a potent insulin secretagogue in the presence of elevated glucose levels, defining glucagon-like peptide-1 as a new incretin. Its action is mediated by specific receptors coupled to the adenylate cyclase system by a stimulatory G-protein. Finally, glucagon-like peptide-1 stimulates proinsulin gene expression and it is thus involved at several levels in the regulation of insulin synthesis and secretion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenylyl Cyclases / metabolism
  • Animals
  • Binding Sites
  • Galanin
  • Gene Expression Regulation
  • Glucagon / metabolism
  • Glucagon / physiology*
  • Glucagon-Like Peptide 1
  • Insulin / metabolism*
  • Insulin Secretion
  • Intestinal Mucosa / cytology
  • Intestinal Mucosa / metabolism*
  • Islets of Langerhans / metabolism*
  • Peptide Fragments / metabolism
  • Peptide Fragments / physiology*
  • Peptides / physiology
  • Proinsulin / genetics
  • Protein Precursors / metabolism
  • Protein Precursors / physiology*
  • Somatostatin / metabolism

Substances

  • Insulin
  • Peptide Fragments
  • Peptides
  • Protein Precursors
  • Somatostatin
  • Galanin
  • Glucagon-Like Peptide 1
  • Glucagon
  • Proinsulin
  • Adenylyl Cyclases