Characterization of group specific antibodies in primates: studies with SIV envelope in macaques

J Med Primatol. 1992 Feb-May;21(2-3):82-90.

Abstract

Sera from SIV-infected macaques were found to contain antibodies that reacted with conformation-dependent, group-specific determinants on the SIV envelope protein gp130. These conformation-dependent antibodies exhibited virus neutralizing activity; their presence was associated with protection in vaccine studies. The properties of these antibodies are quite similar to those that have been identified in sera from HIV-infected human subjects. These data suggest that the SIV envelope gp130 remains a candidate for subunit vaccine studies.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Viral / blood*
  • Blotting, Western
  • CHO Cells
  • Cricetinae
  • Disease Models, Animal
  • Enzyme-Linked Immunosorbent Assay
  • HIV-1 / immunology
  • Immune Sera / immunology
  • Macaca*
  • Neutralization Tests
  • Radioimmunoprecipitation Assay
  • Recombinant Proteins / immunology
  • Simian Acquired Immunodeficiency Syndrome / immunology*
  • Simian Immunodeficiency Virus / immunology*
  • Vaccines, Inactivated / immunology
  • Viral Envelope Proteins / immunology*
  • Viral Vaccines / immunology

Substances

  • Antibodies, Viral
  • Immune Sera
  • Recombinant Proteins
  • Vaccines, Inactivated
  • Viral Envelope Proteins
  • Viral Vaccines