Abstract
Sera from SIV-infected macaques were found to contain antibodies that reacted with conformation-dependent, group-specific determinants on the SIV envelope protein gp130. These conformation-dependent antibodies exhibited virus neutralizing activity; their presence was associated with protection in vaccine studies. The properties of these antibodies are quite similar to those that have been identified in sera from HIV-infected human subjects. These data suggest that the SIV envelope gp130 remains a candidate for subunit vaccine studies.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Viral / blood*
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Blotting, Western
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CHO Cells
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Cricetinae
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Disease Models, Animal
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Enzyme-Linked Immunosorbent Assay
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HIV-1 / immunology
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Immune Sera / immunology
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Macaca*
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Neutralization Tests
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Radioimmunoprecipitation Assay
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Recombinant Proteins / immunology
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Simian Acquired Immunodeficiency Syndrome / immunology*
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Simian Immunodeficiency Virus / immunology*
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Vaccines, Inactivated / immunology
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Viral Envelope Proteins / immunology*
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Viral Vaccines / immunology
Substances
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Antibodies, Viral
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Immune Sera
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Recombinant Proteins
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Vaccines, Inactivated
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Viral Envelope Proteins
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Viral Vaccines