Melatonin induced increase in gamma-interferon production by murine splenocytes

Immunol Lett. 1992 Jul;33(2):123-6. doi: 10.1016/0165-2478(92)90035-m.

Abstract

Previously, we demonstrated that production of gamma-interferon (gamma-IFN) by the mouse splenocytes isolated at night was higher than from those isolated in the morning. In this paper we show that melatonin increased gamma-IFN production by murine splenocytes. Moreover, this stimulating effect was significantly higher (10 times) in the cells isolated at night than in those isolated in the morning (2 times).

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cells, Cultured
  • Circadian Rhythm*
  • Concanavalin A
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Interferon-gamma / metabolism*
  • Melatonin / pharmacology*
  • Mice
  • Mice, Inbred C57BL
  • Receptors, Interleukin-2 / metabolism
  • Spleen / cytology
  • Spleen / drug effects*

Substances

  • Receptors, Interleukin-2
  • Concanavalin A
  • Interferon-gamma
  • Melatonin