Gastrointestinal mucositis: a new biological model

Dorothy M K Keefe

doi:10.1007/s00520-003-0550-9

Gastrointestinal mucositis: a new biological model

Support Care Cancer. 2004 Jan;12(1):6-9. doi: 10.1007/s00520-003-0550-9. Epub 2003 Nov 5.

Author

Dorothy M K Keefe¹

Affiliation

¹ Department of Medical Oncology, Royal Adelaide Hospital, SA 5000 Adelaide, Australia. dkeefe@mail.rah.sa.gov.au

PMID: 14605986
DOI: 10.1007/s00520-003-0550-9

Abstract

The history of research into gastrointestinal mucositis (GIM), and how the future directions are informed by the progress made in the study of oral mucositis (OM) are discussed. It is proposed that OM and GIM should both be considered to be elements of alimentary mucositis (AM), which covers mucosal damage through the entire alimentary tract, with regional differences being due to the specialized needs of each area.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / adverse effects*
Biomarkers, Tumor / metabolism
Gastrointestinal Tract / drug effects*
Humans
Interleukin-11 / metabolism
Keratinocytes / drug effects
Mouth / drug effects*
Mucositis / chemically induced*
Mucositis / metabolism
Nutritional Status
Proto-Oncogene Proteins c-bcl-2 / drug effects

Substances

Antineoplastic Agents
Biomarkers, Tumor
Interleukin-11
Proto-Oncogene Proteins c-bcl-2