The amino acid sequence of a mammalian MAP kinase kinase

Oncogene. 1992 Dec;7(12):2555-6.

Abstract

The amino acid sequence of the dual specificity mitogen-activated protein kinase kinase (MAPKK) has been determined by cDNA cloning and amino acid sequencing. MAPKK (393 residues, Mr 43,330) is a new member of the protein kinase subclass that comprises byr1 and STE7 that are involved in pheromone dependent signal transduction in yeast, wis1 a mitotic regulator in S. pombe and PBS2, which confers antibiotic resistance in S. cerevisiae.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Mitogen-Activated Protein Kinase Kinases
  • Molecular Sequence Data
  • Protein Kinases / chemistry
  • Protein Kinases / genetics*
  • Rabbits
  • Saccharomyces cerevisiae / physiology
  • Schizosaccharomyces / physiology
  • Sequence Homology, Amino Acid
  • Signal Transduction

Substances

  • Protein Kinases
  • Mitogen-Activated Protein Kinase Kinases