Abstract
Antinephritis activity of 5 prenylflavonoids similar to glabridin (1-5), isolated from Morus alba, Artocarpus communis, Glycyrrhiza uralensis and G. inflata, was evaluated in mice with glomerular disease (Masugi-nephritis). Oral administrations of artonin E (2) or licochalcone A (4) for 10 days (30 mg kg(-1) day(-1)) reduced the amount of urinary protein excretion compared to nephritic mice. ESR spectroscopy demonstrated that morusin (1) and licorisoflavan A (5) increased the radical intensity of sodium ascorbate by about two times. Morusin, licoricidin (3), licochalcone A and licorisoflavan A showed weak scavenging activity against superoxide anion radical.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Animals
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Blood Urea Nitrogen
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Cholesterol / blood
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Creatinine / blood
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Flavonoids / administration & dosage
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Flavonoids / pharmacology
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Flavonoids / therapeutic use
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Free Radical Scavengers / administration & dosage
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Free Radical Scavengers / pharmacology*
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Free Radical Scavengers / therapeutic use
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Glomerular Filtration Rate / drug effects
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Mice
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Nephritis / drug therapy*
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
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Plant Roots
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Plants, Medicinal*
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Protein Prenylation
Substances
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Flavonoids
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Free Radical Scavengers
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Plant Extracts
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Cholesterol
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Creatinine