Ureas of 5-aminopyrazole and 2-aminothiazole inhibit growth of gram-positive bacteria

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4463-6. doi: 10.1016/j.bmcl.2003.09.013.

Abstract

Ureas of 5-aminopyrazole and 2-aminothiazole emerged as lead compounds from a high-throughput screen assaying the growth of Staphylococcus aureus. Structure-activity relationships were developed for each compound series. Several compounds were also tested for activity against drug resistant strains of S. aureus in vivo.

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Gram-Positive Bacteria / drug effects*
  • Methicillin Resistance
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Molecular Structure
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / chemistry
  • Pyrazoles / pharmacology*
  • Staphylococcus aureus / drug effects
  • Structure-Activity Relationship
  • Thiazoles / chemical synthesis*
  • Thiazoles / chemistry
  • Thiazoles / pharmacology*
  • Urea / analogs & derivatives*
  • Urea / chemical synthesis*
  • Urea / chemistry
  • Urea / pharmacology

Substances

  • Anti-Bacterial Agents
  • Pyrazoles
  • Thiazoles
  • Urea