[Evaluation of the reliability of three different hepatitis E diagnosis reagents on the clinical acute hepatitis E]

Zhonghua Gan Zang Bing Za Zhi. 2004 Jan;12(1):16-7.
[Article in Chinese]

Abstract

Objective: To evaluate the reliability of different hepatitis E diagnosis reagent tests on the acute hepatitis E.

Methods: Three acute hepatitis E diagnosis tests, E2-IgM (Wantai, China), GL-IgM and GL-IgG (Genelabs, Singapore) were compared for their reliability in a sera panel composed by 273 healthy individuals and 525 hepatitis.

Results: The specificity of E2-IgM on the diagnosis of acute hepatitis E was 100.0%, it was significantly higher than GL-IgM (96.7%) and GL-IgG (85.4%). The sensitivity of E2-IgM and GL-IgG were 97.9% and 93.8% respectively, both significantly higher than GL-IgM (72.9%). Among 65 acute hepatitis cases being positive on GL-IgM test but negative on E2-IgM, 58 (89.2%) cases were found to be positive with anti-hepatitis A virus IgM, it indicated that the GL-IgM test might be interfered by other IgM antibodies on serum.

Conclusion: E2-IgM is a good test for the diagnosis of acute hepatitis E.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Hepatitis Antibodies / blood
  • Hepatitis E / diagnosis*
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin M / blood
  • Reagent Kits, Diagnostic*
  • Sensitivity and Specificity

Substances

  • Hepatitis Antibodies
  • Immunoglobulin G
  • Immunoglobulin M
  • Reagent Kits, Diagnostic