Intraperitoneal cisplatin chemotherapy in ovarian carcinoma patients who are clinically in complete remission

Gynecol Oncol. 1992 Aug;46(2):222-5. doi: 10.1016/0090-8258(92)90259-l.

Abstract

Three courses of intraperitoneal cisplatin chemotherapy with systemic thiosulfate protection were administered to 31 stage II-IV ovarian carcinoma patients who were clinically in complete remission after completion of postoperative cisplatin-based combination chemotherapy. The 5-year survival rate was 60.4% and the median progression-free interval 35 months. Among 25 patients who underwent second-look laparotomy, the survival and the duration of the progression-free interval were significantly better in those with a pathologically confirmed complete response. Short-term intraperitoneal cisplatin chemotherapy should be considered for consolidation of treatment in ovarian carcinoma patients who are clinically in complete remission.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cisplatin / administration & dosage*
  • Cisplatin / adverse effects
  • Female
  • Humans
  • Infusions, Parenteral
  • Middle Aged
  • Neoplasm Staging
  • Ovarian Neoplasms / drug therapy*
  • Ovarian Neoplasms / mortality
  • Ovarian Neoplasms / pathology
  • Postoperative Care
  • Remission Induction
  • Survival Rate
  • Thiosulfates / therapeutic use

Substances

  • Thiosulfates
  • Cisplatin