Leualacin, a novel calcium blocker from Hapsidospora irregularis. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties

K Hamano; M Kinoshita; K Furuya; M Miyamoto; Y Takamatsu; A Hemmi; K Tanzawa

doi:10.7164/antibiotics.45.899

Leualacin, a novel calcium blocker from Hapsidospora irregularis. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties

J Antibiot (Tokyo). 1992 Jun;45(6):899-905. doi: 10.7164/antibiotics.45.899.

Authors

K Hamano¹, M Kinoshita, K Furuya, M Miyamoto, Y Takamatsu, A Hemmi, K Tanzawa

Affiliation

¹ Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.

PMID: 1500357
DOI: 10.7164/antibiotics.45.899

Abstract

A new calcium blocker, designated leualacin, has been isolated from Hapsidospora irregularis. The compound inhibits the binding of 3H-nitrendipine, a well known synthetic calcium blocker, to cardiac Ca channel in a competitive manner, although its structure is completely different from dihydropyridines.

MeSH terms

Animals
Calcium Channel Blockers / chemistry
Calcium Channel Blockers / isolation & purification*
Calcium Channel Blockers / pharmacology
Fermentation*
Fungi / classification*
Fungi / metabolism
Guinea Pigs
Male
Peptides, Cyclic / isolation & purification*
Peptides, Cyclic / pharmacology
Rats
Rats, Inbred SHR

Substances

Calcium Channel Blockers
Peptides, Cyclic
leualacin