Abstract
The authors investigated the relationship between statin use and the risk of stroke in the Heart and Estrogen-Progestin Replacement Study (HERS). Despite large reductions in relative risk point estimates, statin use was not associated with differences in the risks of all fatal stroke (relative hazard [RH] 0.52, 95% CI 0.23 to 1.18, p = 0.12), fatal ischemic stroke (RH 0.51, 95% CI 0.18 to 1.45, p = 0.21), fatal hemorrhagic stroke (RH 0.18, 95% CI 0.02 to 1.46, p = 0.11), or TIA (RH 1.32, 95% CI 0.84 to 2.09, p = 0.23).
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Cohort Studies
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Coronary Disease / drug therapy
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Estrogen Replacement Therapy*
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Estrogens, Conjugated (USP) / therapeutic use
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Female
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
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Incidence
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Ischemic Attack, Transient / epidemiology*
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Medroxyprogesterone Acetate / therapeutic use
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Postmenopause
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Randomized Controlled Trials as Topic / statistics & numerical data
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Risk
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Stroke / mortality*
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Stroke / prevention & control
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Survival Analysis
Substances
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Estrogens, Conjugated (USP)
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Medroxyprogesterone Acetate