Statin use and stroke outcomes in the Heart and Estrogen-Progestin Replacement Study (HERS)

Neurology. 2004 Mar 23;62(6):968-70. doi: 10.1212/01.wnl.0000115171.46508.19.

Abstract

The authors investigated the relationship between statin use and the risk of stroke in the Heart and Estrogen-Progestin Replacement Study (HERS). Despite large reductions in relative risk point estimates, statin use was not associated with differences in the risks of all fatal stroke (relative hazard [RH] 0.52, 95% CI 0.23 to 1.18, p = 0.12), fatal ischemic stroke (RH 0.51, 95% CI 0.18 to 1.45, p = 0.21), fatal hemorrhagic stroke (RH 0.18, 95% CI 0.02 to 1.46, p = 0.11), or TIA (RH 1.32, 95% CI 0.84 to 2.09, p = 0.23).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cohort Studies
  • Coronary Disease / drug therapy
  • Estrogen Replacement Therapy*
  • Estrogens, Conjugated (USP) / therapeutic use
  • Female
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Incidence
  • Ischemic Attack, Transient / epidemiology*
  • Medroxyprogesterone Acetate / therapeutic use
  • Postmenopause
  • Randomized Controlled Trials as Topic / statistics & numerical data
  • Risk
  • Stroke / mortality*
  • Stroke / prevention & control
  • Survival Analysis

Substances

  • Estrogens, Conjugated (USP)
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Medroxyprogesterone Acetate