The role of 99mTc mebrofenin hepatobiliary scanning in predicting common bile duct stones in patients with gallstone disease

Nucl Med Commun. 2004 Mar;25(3):285-9. doi: 10.1097/00006231-200403000-00012.

Abstract

Background: A dilated common bile duct and/or elevated serum alkaline phosphatase, raises a suspicion of bile duct stone(s) in patients with gallstones. Cholangiography, either endoscopic retrograde cholangiopancreatography (ERCP) or magnetic resonance cholangiopancreatography (MRCP), is the best method for diagnosing bile duct stones. ERCP has the disadvantage of being invasive, and there is a risk of complications; while MRCP is costly and is not widely available.

Aim: The objective of the present study was to evaluate the role of hepatobiliary nuclear scanning in diagnosing bile duct stones.

Methods: Twenty-five patients with suspected common bile duct (CBD) stones underwent hepatobiliary scintigraphy. The results of scintigraphy were compared with cholangiograms obtained by ERCP in 11 patients and MRCP in 14 patients, considering MRCP/ERCP as the 'gold standard'.

Results: Scintigraphy showed features suggestive of CBD stones in 11 of the 25 patients. The results of ERCP/MRCP confirmed that eight of them had stones. Scintigraphy showed no features of CBD stones in the remaining 14 patients. ERCP/MRCP showed CBD stones in two of these 14 patients. Thus, scintigraphy had a sensitivity of 80% and a specificity of 80%.

Conclusion: We conclude that scintigraphy has good sensitivity and specificity in predicting CBD stones in patients with gallstone disease and a dilated CBD.

Publication types

  • Clinical Trial
  • Validation Study

MeSH terms

  • Adult
  • Aged
  • Aniline Compounds
  • Biliary Tract / diagnostic imaging
  • Cholangiography
  • Choledocholithiasis / complications
  • Choledocholithiasis / diagnostic imaging*
  • Common Bile Duct / diagnostic imaging*
  • Common Bile Duct / pathology*
  • Dilatation, Pathologic / diagnostic imaging*
  • Dilatation, Pathologic / etiology
  • Female
  • Gallstones / complications
  • Gallstones / diagnostic imaging*
  • Glycine
  • Humans
  • Imino Acids*
  • Liver / diagnostic imaging
  • Male
  • Middle Aged
  • Organotechnetium Compounds*
  • Prognosis
  • Radionuclide Imaging
  • Radiopharmaceuticals
  • Reproducibility of Results
  • Sensitivity and Specificity

Substances

  • Aniline Compounds
  • Imino Acids
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • technetium Tc 99m mebrofenin
  • Glycine