Abstract
We report here on characterization of a novel human gene on chromosome 2q32, containing several ankyrin repeats and ARM domains. The gene FLJ25415, including at least 31 exons and spanning about 90kb of a gene-rich genomic region, is present in the human genome as a single copy. It seems highly conserved along the mammalian phylogeny. By analysing FLJ25415 gene expression in different human tissues, we demonstrated a ubiquitously expression pattern with extensive alternative splicing. In silico prediction of promoter regions revealed the presence of a TATA box and some hypothetical transcription factor binding sites, such as TMF, C/EBPalpha, LE-1, and NF-ATp.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alternative Splicing
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Animals
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Ankyrin Repeat / genetics*
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Base Sequence
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Binding Sites
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DNA, Complementary / genetics
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Exons / genetics
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Expressed Sequence Tags
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Gene Expression
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Genes / genetics
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Humans
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Introns / genetics
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Mice
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Molecular Sequence Data
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Nerve Tissue Proteins / chemistry*
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Nerve Tissue Proteins / genetics*
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Polyadenylation
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Promoter Regions, Genetic / genetics
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Protein Structure, Tertiary
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RNA, Messenger / genetics
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Sequence Alignment
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TATA Box / genetics
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Transcription Initiation Site
Substances
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DNA, Complementary
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Nerve Tissue Proteins
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RNA, Messenger
Associated data
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GENBANK/AJ549812
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GENBANK/AK030065
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GENBANK/AK045669
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RefSeq/NM_028091
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RefSeq/NM_176980
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RefSeq/NP_795954
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RefSeq/XM_234772