An IL-8 gene promoter polymorphism is associated with the risk of the development of AIDS-related Kaposi's sarcoma: a case-control study

Antoinette C van der Kuyl; Abeltje M Polstra; Gerrit Jan Weverling; Fokla Zorgdrager; Remco van den Burg; Marion Cornelissen

doi:10.1097/00002030-200405210-00016

An IL-8 gene promoter polymorphism is associated with the risk of the development of AIDS-related Kaposi's sarcoma: a case-control study

AIDS. 2004 May 21;18(8):1206-8. doi: 10.1097/00002030-200405210-00016.

Authors

Antoinette C van der Kuyl¹, Abeltje M Polstra, Gerrit Jan Weverling, Fokla Zorgdrager, Remco van den Burg, Marion Cornelissen

Affiliation

¹ Department of Human Retrovirology, Academic Medical Centre, University of Amsterdam, The Netherlands.

PMID: 15166538
DOI: 10.1097/00002030-200405210-00016

Abstract

In a case-control study, we studied the effect of a single nucleotide polymorphism in the IL-8 promoter on the risk of the development of AIDS-related Kaposi's sarcoma (KS). KS developed in 46% of individuals with the TT genotype and in 66% of AA/AT genotypes (P=0.038). Patients with TT genotype were rarely affected with visceral KS (7% versus 36%; P=0.06), which suggests that carriers of the TT genotype are protected from (severe) KS development.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

AIDS-Related Opportunistic Infections / genetics
Acquired Immunodeficiency Syndrome / genetics*
Case-Control Studies
Genotype
Humans
Interleukin-8 / genetics*
Odds Ratio
Polymorphism, Genetic / genetics*
Promoter Regions, Genetic / genetics*
Risk Factors
Sarcoma, Kaposi / genetics*

Substances

Interleukin-8