Another fork in the road: Foxo3a regulates NF-kappaB activation

Helen Su; Nicolas Bidere; Michael Lenardo

doi:10.1016/j.immuni.2004.07.015

Another fork in the road: Foxo3a regulates NF-kappaB activation

Immunity. 2004 Aug;21(2):133-4. doi: 10.1016/j.immuni.2004.07.015.

Authors

Helen Su¹, Nicolas Bidere, Michael Lenardo

Affiliation

¹ Molecular Development Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

PMID: 15308093
DOI: 10.1016/j.immuni.2004.07.015

Abstract

Previous studies have implicated the transcription factor FoxO3a in apoptosis induction. Thus, it comes as a surprise in this issue of Immunity that lymphoproliferative disease in Foxo3a-deficient mice may be due to T cell hyperactivity instead of cell death defects. Lin and colleagues provide important new evidence that disease development is associated with NF-kappaB hyperactivation in T cells.

Publication types

Comment

MeSH terms

Animals
Forkhead Box Protein O3
Forkhead Transcription Factors
Lymphoproliferative Disorders / etiology
Lymphoproliferative Disorders / metabolism
Mice
NF-kappa B / immunology
NF-kappa B / metabolism*
Phosphatidylinositol 3-Kinases / immunology
Phosphatidylinositol 3-Kinases / metabolism
T-Lymphocytes / metabolism
Transcription Factors / deficiency
Transcription Factors / immunology
Transcription Factors / metabolism*

Substances

Forkhead Box Protein O3
Forkhead Transcription Factors
FoxO3 protein, mouse
NF-kappa B
Transcription Factors
Phosphatidylinositol 3-Kinases