Effects of stereotactic neurosurgery on postural instability and gait in Parkinson's disease

Mov Disord. 2004 Sep;19(9):1092-9. doi: 10.1002/mds.20116.

Abstract

Postural instability and gait disability (PIGD) are disabling signs of Parkinson's disease. Stereotactic surgery aimed at the internal globus pallidus (GPi) or subthalamic nucleus (STN) might improve PIGD, but the precise effects remain unclear. We performed a systematic review of studies that examined the effects of GPi or STN surgery on PIGD. Most studies examined the effects of bilateral GPi stimulation, bilateral STN stimulation, and unilateral pallidotomy; we, therefore, only performed a meta-analysis on these studies. Bilateral GPi stimulation, bilateral STN stimulation, and to a lesser extent, unilateral pallidotomy significantly improved PIGD, and more so during the ON phase than during the OFF phase.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Gait*
  • Globus Pallidus / surgery
  • Humans
  • Parkinson Disease / physiopathology*
  • Parkinson Disease / surgery*
  • Posture*
  • Radiosurgery / instrumentation*
  • Subthalamic Nucleus / surgery
  • Surveys and Questionnaires
  • Time Factors