Abstract
Multiple human immunodeficiency virus type-1 sequences from the V3 and V4-V5 regions of the envelope gene were analyzed from three mother-infant pairs. The infants' viral sequences were less diverse than those of their mothers. In two pairs, a proviral form infrequently found in the mother predominated in her infant. A conserved N-linked glycosylation site within the V3 region, present in each mother's sequence set, was absent in all of the infants' sequence sets. These findings demonstrate that a minor subset of maternal virus is transmitted to the infant.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acquired Immunodeficiency Syndrome / congenital
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Acquired Immunodeficiency Syndrome / microbiology
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Acquired Immunodeficiency Syndrome / transmission*
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Amino Acid Sequence
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Base Sequence
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Female
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Genotype
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Glycosylation
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HIV Antigens / genetics
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HIV Envelope Protein gp120 / genetics
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HIV Envelope Protein gp120 / immunology
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HIV-1 / genetics*
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HIV-1 / immunology
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Humans
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Infant
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Maternal-Fetal Exchange
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Molecular Sequence Data
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Oligodeoxyribonucleotides / chemistry
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Polymerase Chain Reaction
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Pregnancy
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Selection, Genetic
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Sequence Alignment
Substances
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HIV Antigens
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HIV Envelope Protein gp120
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Oligodeoxyribonucleotides
Associated data
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GENBANK/M76788
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GENBANK/M76789
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GENBANK/M76790
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GENBANK/M76791
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GENBANK/M76792
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GENBANK/M76793
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GENBANK/M76794
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GENBANK/M76795
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GENBANK/M76796
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GENBANK/M76797
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GENBANK/M76798
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GENBANK/M76799
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GENBANK/M76800
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GENBANK/M76801
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GENBANK/M76802
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GENBANK/M76803
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GENBANK/M76804
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GENBANK/M76805
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GENBANK/M76806
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GENBANK/M76807
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GENBANK/M76808
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GENBANK/M76809
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GENBANK/M76810
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GENBANK/M76811
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GENBANK/M76812
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GENBANK/M76813
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GENBANK/M76814
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GENBANK/M76815
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GENBANK/M76816
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GENBANK/M76817