Malignancies, including oral Kaposi's sarcoma, may develop in transplant patients as a result of immunosuppressive therapy. Both the prevalence and the incidence of these malignancies vary. This article describes a renal transplant patient who was receiving immunosuppressive therapy and presented with oral Kaposi's sarcoma. The lesion was excised and did not recur. However, the patient died as a result of viral pneumonitis, secondary to her renal problems. The article also includes a review of the literature, with particular emphasis on oral presentation of immunosuppression-related malignancies.