Overstretching of sarcomeres may not cause cerebral palsy muscle contracture

J Orthop Res. 2004 Nov;22(6):1331-5. doi: 10.1016/j.orthres.2004.04.006.

Abstract

To answer the question whether the muscle contracture in patients with cerebral palsy is caused by overstretching of in-series sarcomeres we studied the active and passive force-length relationship of the flexor carpi ulnaris muscle (FCU) in relation to its operating length range in 14 such patients with a flexion deformity of the wrist. Force-length relationship was measured intra-operatively using electrical stimulation, a force transducer, and a data-acquisition system. Muscle length was measured in maximally flexed and maximally extended position of the wrist. The spastic FCU was found to exert over 80% of its maximum active force at maximal extension of the wrist and this indicates abundant overlap of the sarcomeres. At maximal wrist extension, FCU passive force corresponded with only 0.7-18% of maximum active force. Both findings imply that the FCU sarcomeres are not overstretched when the wrist is extended. We conclude that the overstretching of in-series sarcomeres appears not to be the cause of contracture of the spastic FCU.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Cerebral Palsy / complications
  • Cerebral Palsy / physiopathology*
  • Child
  • Contracture / etiology
  • Contracture / physiopathology*
  • Female
  • Humans
  • Male
  • Muscle Contraction
  • Muscle Spasticity / etiology
  • Muscle Spasticity / physiopathology
  • Sarcomeres / physiology*
  • Wrist Joint