Abstract
The virulence plasmid of human pathogenic Yersinia species, pYV, encodes secreted proteins, Yop proteins, and an outer membrane protein, YadA. YadA has been associated with binding to a variety of substrates and with interference with host defense. YadA is regulated by temperature and is expressed only at 37 degrees C. Unlike the yop regulon, the yadA gene is not under Ca2+ regulation. Here, we show that LcrF (VirF), the temperature-regulated activator of the yop regulon, also acts as an activator for yadA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Outer Membrane Proteins / genetics*
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Base Sequence
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Cloning, Molecular
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Gene Expression Regulation, Bacterial*
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Genes, Bacterial
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Molecular Sequence Data
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Oligodeoxyribonucleotides / chemistry
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Plasmids
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Polymerase Chain Reaction
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Temperature
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Yersinia enterocolitica / genetics*
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Yersinia enterocolitica / pathogenicity
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Yersinia pseudotuberculosis / genetics*
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Yersinia pseudotuberculosis / pathogenicity
Substances
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Bacterial Outer Membrane Proteins
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Oligodeoxyribonucleotides