Abstract
EGF-TM7 receptors are adhesion class heptahelical molecules predominantly expressed by cells of the immune system. Based on an analysis of the recently unraveled genome, the EGF-TM7 family of the rat is described here. Like the mouse, the rat has three EGF-TM7 receptors--CD97, EMR1 and EMR4. The highest conservation between the orthologues lies within the membrane-spanning part and emphasizes the functional importance of this region.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Calcium-Binding Proteins
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Epidermal Growth Factor / genetics
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ErbB Receptors / genetics*
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Genome
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Membrane Glycoproteins / genetics
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Mice
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Molecular Sequence Data
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Mucins / genetics
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Multigene Family*
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Protein Structure, Tertiary
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Rats
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Receptors, Cell Surface / genetics*
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Receptors, G-Protein-Coupled
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Sequence Homology, Amino Acid
Substances
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ADGRE1 protein, human
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Adgre1 protein, rat
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Adgre4 protein, rat
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Adgre5 protein, mouse
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Adgre5 protein, rat
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Calcium-Binding Proteins
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Emr4 protein, mouse
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Membrane Glycoproteins
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Mucins
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Receptors, Cell Surface
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Receptors, G-Protein-Coupled
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Epidermal Growth Factor
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ErbB Receptors
Associated data
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GENBANK/AY686632
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GENBANK/AY686633