Abstract
Effective defense against diverse types of micro-organisms that invade our body requires specialized classes of antigen-specific immune responses initiated and maintained by distinct subsets of effector CD4(+) T helper (Th) cells. Excessive or detrimental (e.g., autoimmune) responses by effector T cells are controlled by regulatory T cells. The optimal balance in the development of the different types of effector and regulatory Th cells is orchestrated by dendritic cells (DC). This review discusses the way DC adapt the T cell response to the type of pathogen, focusing on the tools that DC use in this management of the T cell response.
MeSH terms
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Animals
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Antigens, CD / immunology
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B7-1 Antigen / immunology
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B7-2 Antigen
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Dendritic Cells / classification
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Dendritic Cells / immunology*
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Humans
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Interferon Type I / immunology
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Interleukin-10 / immunology
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Interleukin-12 / immunology
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Interleukin-18 / immunology
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Interleukin-4 / immunology
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Membrane Glycoproteins / immunology
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Models, Immunological
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OX40 Ligand
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Signal Transduction
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T-Lymphocytes, Helper-Inducer / classification
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T-Lymphocytes, Helper-Inducer / immunology*
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Th1 Cells / immunology
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Th2 Cells / immunology
Substances
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Antigens, CD
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B7-1 Antigen
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B7-2 Antigen
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CD86 protein, human
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Interferon Type I
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Interleukin-18
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Membrane Glycoproteins
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OX40 Ligand
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TNFSF4 protein, human
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Interleukin-10
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Interleukin-12
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Interleukin-4