Abstract
Novel nucleoside antibiotics were isolated from the cultured broth of the strain classified as Streptomyces sp. SANK 62799. The strain produced four novel capuramycin derivatives designated as A-503083 A, B, E and F. Their structures were elucidated as 2'-O-carbamoyl derivatives of A-500359 A, B (capuramycin), E and F, respectively. A-503083 A, B, E and F inhibited bacterial phospho-N-acetylmuramyl-pentapeptide-translocase (translocase I: EC 2.7.8.13) with IC50 values of 0.024, 0.038, 0.135 and 17.9 microM, respectively.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Azepines / chemistry
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Azepines / isolation & purification*
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Azepines / pharmacology
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Bacteria / enzymology*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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Streptomyces / classification
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Streptomyces / metabolism*
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Transferases (Other Substituted Phosphate Groups) / antagonists & inhibitors*
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Uridine / analogs & derivatives*
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Uridine / chemistry
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Uridine / isolation & purification*
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Uridine / pharmacology
Substances
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A 503083 A
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A 503083 B
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A 503083 E
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A 503083 F
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Anti-Bacterial Agents
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Azepines
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Enzyme Inhibitors
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Transferases (Other Substituted Phosphate Groups)
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phospho-N-acetylmuramoyl pentapeptide transferase
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Uridine