A-503083 A, B, E and F, novel inhibitors of bacterial translocase I, produced by Streptomyces sp. SANK 62799

J Antibiot (Tokyo). 2004 Oct;57(10):639-46. doi: 10.7164/antibiotics.57.639.

Abstract

Novel nucleoside antibiotics were isolated from the cultured broth of the strain classified as Streptomyces sp. SANK 62799. The strain produced four novel capuramycin derivatives designated as A-503083 A, B, E and F. Their structures were elucidated as 2'-O-carbamoyl derivatives of A-500359 A, B (capuramycin), E and F, respectively. A-503083 A, B, E and F inhibited bacterial phospho-N-acetylmuramyl-pentapeptide-translocase (translocase I: EC 2.7.8.13) with IC50 values of 0.024, 0.038, 0.135 and 17.9 microM, respectively.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Azepines / chemistry
  • Azepines / isolation & purification*
  • Azepines / pharmacology
  • Bacteria / enzymology*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • Streptomyces / classification
  • Streptomyces / metabolism*
  • Transferases (Other Substituted Phosphate Groups) / antagonists & inhibitors*
  • Uridine / analogs & derivatives*
  • Uridine / chemistry
  • Uridine / isolation & purification*
  • Uridine / pharmacology

Substances

  • A 503083 A
  • A 503083 B
  • A 503083 E
  • A 503083 F
  • Anti-Bacterial Agents
  • Azepines
  • Enzyme Inhibitors
  • Transferases (Other Substituted Phosphate Groups)
  • phospho-N-acetylmuramoyl pentapeptide transferase
  • Uridine