SNP haplotypes in the angiotensin I-converting enzyme (ACE) gene: analysis of Nigerian family data using gamete competition models

Ann Hum Genet. 2005 Mar;69(Pt 2):227-32. doi: 10.1046/j.1529-8817.2004.00142.x.

Abstract

Gamete competition models were used to explore the relationships between 13 ACE gene polymorphisms and plasma ACE concentration in a set of Nigerian families. Several markers in the 5' and 3' regions of the gene were significantly associated with ACE concentration (P < 10(-4)). Multi-locus genotypes comprising different combinations of markers from the 5' UTR and the 3' region of the gene were also analysed; in addition to G2350A, in the 3' region, two markers from the 5' UTR (A-5466C and A-240T) were found to be associated with ACE concentration. These results are consistent with reports that have suggested the presence of at least two ACE-linked QTLs, and demonstrate the utility of gamete competition models in the exploratory investigation of the relationship between a quantitative trait and multiple variants in a small genomic region.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Female
  • Germ Cells*
  • Haplotypes*
  • Humans
  • Male
  • Middle Aged
  • Models, Biological*
  • Nigeria
  • Peptidyl-Dipeptidase A / genetics*
  • Polymorphism, Single Nucleotide*

Substances

  • Peptidyl-Dipeptidase A