Transvalencin A, a thiazolidine zinc complex antibiotic produced by a clinical isolate of Nocardia transvalensis. I. Taxonomy, fermentation, isolation and biological activities

J Antibiot (Tokyo). 2004 Dec;57(12):797-802. doi: 10.7164/antibiotics.57.797.

Abstract

A new thiazolidine-type antibiotic with zinc in its structure, designated transvalencin A, was isolated from Nocardia sp. IFM 10065, a clinical isolate from a patient with actinomycotic mycetoma. The strain was identified as Nocardia transvalensis based on its morphological, phenotypic and phylogenetic characteristics. Transvalencin A showed antimicrobial activity against fungi such as Trichophyton mentagrophytes and Cryptococcus neoformans. The antibiotic is also active against Gram-positive bacteria such as Micrococcus luteus. We observed higher activity for fungi in an acidic medium than in a neutral medium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents* / isolation & purification
  • Anti-Bacterial Agents* / pharmacology
  • Fermentation
  • Microscopy, Electron, Scanning
  • Nocardia / chemistry*
  • Nocardia / classification
  • Nocardia / ultrastructure
  • Organometallic Compounds* / isolation & purification
  • Organometallic Compounds* / pharmacology
  • Phylogeny
  • Thiazoles* / isolation & purification
  • Thiazoles* / pharmacology
  • Zinc / chemistry*

Substances

  • Anti-Bacterial Agents
  • Organometallic Compounds
  • Thiazoles
  • transvalencin A
  • Zinc