Transvalencin A, a thiazolidine zinc complex antibiotic produced by a clinical isolate of Nocardia transvalensis. II. Structure elucidation

J Antibiot (Tokyo). 2004 Dec;57(12):803-7. doi: 10.7164/antibiotics.57.803.

Abstract

A novel antifungal antibiotic, transvalencin A, is produced by Nocardia transvalensis IFM 10065 isolated from a patient with actinomycotic mycetoma in Japan. The antibiotic structure was elucidated using NMR, mass spectrometric investigations, and X-ray crystallographic analysis. Transvalencin A is a 1:1 complex of a zinc and an organic acid with a phenolic substituent. Transvalencin A is comprised of o-substituted p-chlorophenol, tetrasubstituted oxazoline, disubstituted thiazolyl-N-methylthiazolidine and monosubstituted N-methylthiazolidine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Models, Molecular
  • Molecular Structure
  • Nocardia / chemistry*
  • Organometallic Compounds / chemistry*
  • Thiazoles / chemistry*
  • Zinc / chemistry*

Substances

  • Anti-Bacterial Agents
  • Organometallic Compounds
  • Thiazoles
  • transvalencin A
  • Zinc