Panel of prototypical infectious molecular HIV-1 clones containing multiple nucleoside reverse transcriptase inhibitor resistance mutations

AIDS. 2005 Apr 29;19(7):731-3. doi: 10.1097/01.aids.0000166098.54564.0c.

Abstract

We have created a panel of recombinant HIV-1 infectious clones containing common patterns of reverse transcriptase (RT) mutations responsible for resistance to each of the currently available nucleoside reverse transcriptase inhibitors (NRTI), and we have submitted the panel to the National Institutes of Health AIDS Research and Reference Reagent Programme. Testing the activity of new antiretroviral compounds against this panel of drug-resistant clones will determine their relative activity against many clinically relevant NRTI-resistant viruses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Clone Cells
  • Drug Resistance, Multiple, Viral / genetics
  • Genotype
  • HIV Infections / virology*
  • HIV Reverse Transcriptase / genetics*
  • HIV-1 / genetics*
  • HIV-1 / isolation & purification*
  • Humans
  • Mutation*
  • RNA, Viral / isolation & purification
  • Reverse Transcriptase Inhibitors
  • Virus Cultivation

Substances

  • RNA, Viral
  • Reverse Transcriptase Inhibitors
  • HIV Reverse Transcriptase