Spectrally programmable light engine for in vitro or in vivo molecular imaging and spectroscopy

Appl Opt. 2005 Apr 10;44(11):2033-40. doi: 10.1364/ao.44.002033.

Abstract

A spectrally and temporally programmable light engine can create any spectral profile for hyperspectral, fluorescence, or principal-component imaging or with medical photonics devices employing spectroscopy, microscopy, and endoscopy. Multispectral imaging feasibility was demonstrated by capturing nine images at wavelengths from 450 to 650 mm (25-nm FWHM) with a CCD-camera-equipped bronchoscope coupled to the light engine. Selected wavelength regions were combined to produce a color endoscopy image.

Publication types

  • Evaluation Study

MeSH terms

  • Bronchoscopes*
  • Equipment Design
  • Equipment Failure Analysis
  • Feasibility Studies
  • Humans
  • Image Enhancement / instrumentation*
  • Image Enhancement / methods
  • Image Interpretation, Computer-Assisted / instrumentation
  • Image Interpretation, Computer-Assisted / methods*
  • Molecular Biology / instrumentation*
  • Molecular Biology / methods
  • Optics and Photonics / instrumentation*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Spectrophotometry / instrumentation*
  • Spectrophotometry / methods