Abstract
The cathepsin B, D and L were studied by immunohistochemical techniques in the human postmortem brain. The enzyme were primarily localized in neurons. Makroglial cells were seldom immunostained. It is shown that cathepsins B and D frequently occur in neuritic plaques of Alzheimer victims, thereby raising the question, whether or not cathepsin immunohistochemistry is a useful tool in the diagnosis of this disease. Furthermore, we identified certain glial cells to be immunoreactive for cathepsins in schizophrenics.
MeSH terms
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Aged
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Aged, 80 and over
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Alzheimer Disease / diagnosis*
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Alzheimer Disease / enzymology
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Astrocytes / enzymology
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Cathepsin B / analysis*
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Cathepsin D / analysis*
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Cathepsin L
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Cathepsins / analysis*
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Cerebral Cortex / enzymology
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Cerebral Cortex / pathology
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Cysteine Endopeptidases
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Endopeptidases*
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Female
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Humans
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Immunohistochemistry
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Male
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Middle Aged
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Neurites / enzymology
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Neuroglia / enzymology
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Schizophrenia / diagnosis*
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Schizophrenia / enzymology
Substances
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Cathepsins
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Endopeptidases
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Cysteine Endopeptidases
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Cathepsin B
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CTSL protein, human
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Cathepsin L
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Cathepsin D