[Expression of SSX2 gene in human urologic neoplasms]

Zhonghua Wai Ke Za Zhi. 2005 Mar 15;43(6):379-81.
[Article in Chinese]

Abstract

Objective: To investigate the expression of SSX(2)gene in human renal cell carcinoma and urinary transitional cell carcinoma.

Methods: Reverse-transcription polymerase chain reaction (RT-PCR) was used for detecting SSX(2) gene in the specimens from renal cell carcinoma (n = 26), urinary transitional cell carcinoma (n = 27) and in 15 specimens taken from the tumor surrounding tissues.

Results: Positive expression of SSX(2) gene at mRNA was detected in 69% renal cell carcinomas (18/26), in 81% urinary transitional cell carcinomas (22/27). The mRNA of SSX(2) was not detected in the 15 specimens from tumor surrounding tissues.

Conclusion: The SSX(2) gene is highly expressed in human renal cell carcinoma and urinary transitional cell carcinoma.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Renal Cell / genetics*
  • Carcinoma, Renal Cell / pathology
  • Carcinoma, Transitional Cell / genetics*
  • Carcinoma, Transitional Cell / pathology
  • Female
  • Gene Expression
  • Humans
  • Kidney Neoplasms / genetics*
  • Kidney Neoplasms / pathology
  • Male
  • Middle Aged
  • Neoplasm Proteins / genetics*
  • RNA, Messenger / genetics
  • Repressor Proteins / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Urethral Neoplasms / genetics*
  • Urethral Neoplasms / pathology

Substances

  • Neoplasm Proteins
  • RNA, Messenger
  • Repressor Proteins
  • synovial sarcoma X breakpoint proteins