Celiac disease (CD) has been long considered as a "European disease" that is rarely seen in the North America. Recent data has refuted this notion and suggested that celiac disease in the United States is as common as in Europe. The atypical clinical presentation of celiac disease was one of the major reasons implicated for the under-diagnosis of this disease in American children. In this report, we describe several case presentations of children with celiac disease in order to update primary care physicians on the pathophysiology, diagnosis, treatment, and prognosis of this increasingly prevalent disease.