TEL/AML1 and immunoreceptor gene rearrangements-which comes first?

Leuk Res. 2005 Jun;29(6):633-9. doi: 10.1016/j.leukres.2004.11.007. Epub 2005 Jan 18.

Abstract

TEL/AML1 fusion gene is present in 20-25% of childhood acute lymphoblastic leukaemias. In order to unravel at which stage of B-cell precursor development the fusion is originated, we analysed frequency and pattern of immunoreceptor (immunoglobulin and T-cell receptor) gene rearrangements in 47 TEL/AML1-positive and 43 TEL/AML1-negative cases of the same CD10+ immunophenotype. Moreover, we compared corresponding immunoreceptor gene rearrangements in 11 cases of TEL/AML1-positive leukaemia at diagnosis and relapse. More mature immunogenotype of TEL/AML1-positive cases and changes in 37% of rearrangements between diagnosis and relapse suggest that in most cases the TEL/AML1 fusion is formed during immunoreceptor gene rearrangement process.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • B-Lymphocytes / immunology
  • Cell Cycle / genetics
  • Core Binding Factor Alpha 2 Subunit
  • Gene Rearrangement
  • Hematopoietic Stem Cells / immunology
  • Humans
  • Immunoglobulins / analysis
  • Immunoglobulins / genetics
  • Immunophenotyping
  • Neprilysin / biosynthesis
  • Neprilysin / immunology
  • Oncogene Proteins, Fusion / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Receptors, Antigen, T-Cell / analysis
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Immunologic / analysis
  • Receptors, Immunologic / genetics*
  • Recurrence

Substances

  • Core Binding Factor Alpha 2 Subunit
  • Immunoglobulins
  • Oncogene Proteins, Fusion
  • Receptors, Antigen, T-Cell
  • Receptors, Immunologic
  • TEL-AML1 fusion protein
  • Neprilysin