Abstract
In vasogenic cerebral oedema, there is progressive quantitative and qualitative impairment of mitochondrial ATPase and of Na/K/ATPase. This impairment, which reflects the intracellular component of cerebral oedema, would appear to be related to changes in the phospholipid environment of the cell membrane enzymes. CDP choline, a metabolic phospholipid precursor, is to a certain extent capable of correcting this disturbed activity and at the same time reduce oedema.
MeSH terms
-
Adenosine Triphosphatases / metabolism*
-
Animals
-
Brain Edema / drug therapy
-
Brain Edema / enzymology*
-
Cell Membrane / enzymology
-
Choline / analogs & derivatives*
-
Cytidine Diphosphate Choline / pharmacology*
-
Cytidine Diphosphate Choline / therapeutic use
-
Mitochondria / enzymology
-
Phospholipids / analysis
-
Potassium / metabolism
-
Rabbits
-
Sodium / metabolism
Substances
-
Phospholipids
-
Cytidine Diphosphate Choline
-
Sodium
-
Adenosine Triphosphatases
-
Choline
-
Potassium