Genetic lesions within the 3a gene of SARS-CoV

Virol J. 2005 Jun 20:2:51. doi: 10.1186/1743-422X-2-51.

Abstract

A series of frameshift mutations within the 3a gene has been observed in culture-derived severe acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical samples obtained from SARS-CoV infected patients also contains a heterogeneous population of wild-type and mutant 3a transcripts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Frameshift Mutation*
  • Humans
  • RNA, Viral / genetics
  • Severe Acute Respiratory Syndrome / virology*
  • Severe acute respiratory syndrome-related coronavirus / genetics*
  • Severe acute respiratory syndrome-related coronavirus / isolation & purification*
  • Viral Envelope Proteins
  • Viral Proteins / genetics*
  • Viroporin Proteins

Substances

  • 3a protein, SARS-CoV
  • RNA, Viral
  • Viral Envelope Proteins
  • Viral Proteins
  • Viroporin Proteins