Abstract
Thrombosis in hemophiliacs is a very unusual event mostly reported in patients treated with concentrates containing large quantities of activated coagulation factors. A patient with hemophilia A is reported who had an acute myocardial infarction and in whom investigation for hereditary thrombophilia showed a prothrombotic molecular defect, the G20210A prothrombin mutation.
MeSH terms
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Amino Acid Substitution
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Factor V / genetics
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Factor VIII / analysis
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Hemophilia A / blood
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Hemophilia A / complications
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Hemophilia A / genetics*
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Humans
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Male
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Middle Aged
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Myocardial Infarction / etiology
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Myocardial Infarction / genetics
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Polymorphism, Single Nucleotide
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Prothrombin / genetics*
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Thrombosis / etiology*
Substances
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factor V Leiden
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Factor V
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Prothrombin
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Factor VIII