Thrombosis in hemophiliacs with prothrombotic molecular defect

Clin Appl Thromb Hemost. 2005 Jul;11(3):359-60. doi: 10.1177/107602960501100318.

Abstract

Thrombosis in hemophiliacs is a very unusual event mostly reported in patients treated with concentrates containing large quantities of activated coagulation factors. A patient with hemophilia A is reported who had an acute myocardial infarction and in whom investigation for hereditary thrombophilia showed a prothrombotic molecular defect, the G20210A prothrombin mutation.

Publication types

  • Case Reports

MeSH terms

  • Amino Acid Substitution
  • Factor V / genetics
  • Factor VIII / analysis
  • Hemophilia A / blood
  • Hemophilia A / complications
  • Hemophilia A / genetics*
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction / etiology
  • Myocardial Infarction / genetics
  • Polymorphism, Single Nucleotide
  • Prothrombin / genetics*
  • Thrombosis / etiology*

Substances

  • factor V Leiden
  • Factor V
  • Prothrombin
  • Factor VIII